SR proteins: To shuttle or not to shuttle, that is the question

SR proteins: To shuttle or not to shuttle, that is the question

Serine- and arginine-rich proteins play important roles in splicing, nuclear export, and translation. In this issue, Botti et al. (2017. J. Cell Biol https://doi.org/10.1083/jcb.201610051) show that SRSF2 and SRSF5, previously thought to be nuclear, shuttle with messenger RNA to the cytoplasm in pluripotent P19 cells, but not in differentiated cells.

coeliac disease: to classify or not to classify – that is the question!

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the student committee of sports medicine research center: to be independent or not to be? that is the question

To scavenge or not to scavenge: that is the question.

Analysis of a series of diffraction data sets measured from four native as well as four nicotinic acid-soaked crystals of trypsin at 100 K shows a high variability in radiation-sensitivity among individual crystals for both nicotinic acid-soaked and native crystals. The level of radiation-sensitivity and the extent of its variability is statistically indistinguishable between the two conditions...

To P or not to P: that is the question.

In 1993 Eugene Harris, a well-known biostatistician at the NIH, wrote an editorial for Clinical Chemistry regarding the use of P values vs confidence intervals in the evaluation of scientific data (1 ). This has long been a contentious topic in the scientific world and one with which each new generation of scientists has had to grapple on the basis of arguments advanced for the use of various s...